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目的:探讨静脉应用3种不同剂量沐舒坦在预防老年患者腹腔镜低位直肠癌术后肺部并发症方面的临床价值。方法:将2010年8月至2011年7月在中山大学附属第六医院行腹腔镜低位直肠癌手术的60例老年患者随机分为A、B、C 3组,A组(20例)常规剂量沐舒坦(30 mg/次,每天3次,连续5 d);B组(20例)中等剂量沐舒坦(90 mg/次,每天3次,连续5 d);C组(20例)较大剂量沐舒坦(300 mg/次,每天2次,连续5 d)。比较3组患者术后排痰情况、肺部并发症、术后平均使用抗生素天数及术后平均住院天数等项目。结果:在咳痰容易程度及痰的性状临床控制方面,B、C组与A组的差异均有统计学意义(P<0.05),B组与C组间差异无统计学意义(P>0.05)。肺部并发症A组与C组间差异有统计学意义(P<0.05),B组与C组间差异无统计学意义(P>0.05)。结论:静脉应用中等剂量沐舒坦在预防老年患者腹腔镜低位直肠癌手术后肺部并发症方面有较好的临床价值。
Objective: To investigate the clinical value of intravenous mucosolvan in three different doses in the prevention of postoperative pulmonary complications of laparoscopic low rectal cancer in elderly patients. Methods: From August 2010 to July 2011, 60 elderly patients undergoing laparoscopic surgery for low rectal cancer at the 6th Affiliated Hospital of Sun Yat-sen University were randomly divided into A, B and C groups. A group (n = 20) (30 mg / time, 3 times a day for 5 consecutive days); group B (20 patients) moderate dose of ambroxol (90 mg / time 3 times a day for 5 consecutive days); group C The dose of ambroxol (300 mg / time, twice a day for 5 consecutive days). The postoperative sputum excretion, pulmonary complications, average postoperative antibiotic days and postoperative average hospitalization days were compared between the three groups. Results: There were significant differences in the ease of sputum and the clinical control of sputum between groups B and C and group A (P <0.05), but there was no significant difference between group B and C (P> 0.05 ). The difference of pulmonary complications between group A and group C was statistically significant (P <0.05). There was no significant difference between group B and group C (P> 0.05). Conclusion: Intravenous moderate dose of ambroxol has good clinical value in preventing lung complications after laparoscopic surgery for lower rectal cancer in elderly patients.