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目的观察阿托伐他汀钙治疗2型糖尿病并高脂血症患者的效果观察。方法选择2012年7月-2015年7月医院收治的2型糖尿病并高脂血症患者120例,随机分为治疗组及对照组各60例。2组患者均给予饮食控制及二甲双胍治疗,治疗组给予阿托伐他汀钙20 mg/d,治疗8周后分析2组患者治疗前后空腹血糖、餐后2h血糖、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及三酰甘油(TG)。结果 2组患者治疗前TC、LDL-C、HDL-C及TG水平比较无明显差异(P>0.05)。2组治疗后患者的TC、LDL-C、TG低于治疗前,HDL-C水平高于治疗前,且治疗组变化幅度大于对照组,差异有统计学意义(P<0.05)。治疗后2组患者的空腹血糖及餐后2h血糖低于治疗前,且治疗组患者血糖下降幅度大于对照组,差异有统计学意义(P<0.05)。结论阿托伐他汀钙治疗2型糖尿病合并高脂血症效果明显,同时联合降糖药物使用时还有降低血糖的疗效。
Objective To observe the effect of atorvastatin calcium on type 2 diabetic patients with hyperlipidemia. Methods A total of 120 patients with type 2 diabetes mellitus and hyperlipidemia admitted from July 2012 to July 2015 in our hospital were randomly divided into treatment group (60 cases) and control group (60 cases). The patients in both groups were given diet control and metformin. The treatment group was given 20 mg a day of atorvastatin calcium. After 8 weeks of treatment, the fasting blood glucose, postprandial blood glucose, total cholesterol (TC), low density Lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG). Results There was no significant difference in the levels of TC, LDL-C, HDL-C and TG between the two groups before treatment (P> 0.05). The levels of TC, LDL-C and TG in patients after treatment were lower than those before treatment and HDL-C before treatment, and the changes in treatment group were greater than those in control group (P <0.05). After treatment, the fasting blood glucose and postprandial blood glucose of 2h group were lower than those before treatment, and the decrease of blood glucose in the treatment group was more than that of the control group, the difference was statistically significant (P <0.05). Conclusions Atorvastatin calcium treatment of type 2 diabetes with hyperlipidemia effect is obvious, combined with hypoglycemic agents also have the effect of reducing blood sugar.