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二氯二甲醚(DDA)化学性质活泼,属α-卤醚,为有窒息性气味的无色液体,是有机合成、生产高分子化合物和杀虫剂等的中间体。由于DDA的水解产物有强烈刺激作用,因此早已被公认为皮肤和粘膜的强刺激剂。本文报导了DDA的动物实验结果以及对人的健康危害。大鼠经口中毒的L_(50)为400毫米~3/公斤体重,小鼠腹腔注射的LD_(50)为6.4毫米~3/公斤体重。小鼠皮肤涂敷实验(2毫克DDA溶于0.1毫升苯/每只,每周3次,共325天)的结果表明,涂敷部位皮肤严重溃烂,动物整体情况不佳。20只动物中13只在涂敷部位周围出现乳突状瘤,其
Dichlorodimethylammonium (DDA) is an active chemical substance and belongs to α-haloether. It is a colorless liquid with suffocating odor and is an intermediate for organic synthesis, production of polymer compounds and pesticides. DDA has long been recognized as a strong irritant to the skin and mucous membranes due to its strong stimulant. This article reports the results of animal experiments on DDA as well as the health risks to humans. The L_ (50) of rat oral poisoning was 400 mm ~ 3 / kg body weight, the LD_ (50) of mice injected intraperitoneally was 6.4 mm ~ 3 / kg body weight. The results of the mouse skin application test (2 mg DDA in 0.1 mL benzene / each, three times a week for a total of 325 days) showed severe skin ulceration at the application site and poor overall animal performance. Thirteen of 20 animals developed papilloma around the site of application