在肿瘤组织中,除了肿瘤细胞外还有其他成分包括间质细胞和细胞外基质(ECM),这些共同构成肿瘤微环境。这些间质细胞包括:成纤维细胞、内皮细胞、炎症细胞、脂肪细胞等。间质细胞的分布、细胞外基质的组成和代谢产物在同一肿瘤中明显不同。肿瘤细胞周围的间质细胞状态对肿瘤的转移产生重要影响,甚至可以用来预测肿瘤复发。肿瘤的发生发展包括众多成分之间的相互作用,本文论述了这一复杂网络的各个组成部分。 In the tumor tissue, in addition to the tumor cells there are other components including stromal cells and extracellular matrix (ECM), which together constitute the tumor microenvironment. These stromal cells include: fibroblasts, endothelial cells, inflammatory cells, adipocytes and the like. The distribution of interstitial cells, the composition of the extracellular matrix, and the metabolites are significantly different in the same tumor. Interstitial cell status around tumor cells has important implications for tumor metastasis and can even be used to predict tumor recurrence. Tumor development involves the interaction of many components. This article discusses the various components of this complex network.