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通过右心漂浮导管检测了２０例临床缓解期慢性阻塞性肺病（ＣＯＰＤ）患者的血流动力学参数，并用放射免疫分析法分别测定了体动脉和肺动脉血浆内皮素－１（ＥＴ－１）水平。结果显示：体动脉血浆ＥＴ－１水平（５７．００±８．８９）ｐｇ／ｍｌ小于肺动脉血浆ＥＴ－１水平（７５．９２±１７．３６）ｐｇ／ｍｌ（Ｐ＜０．００１）：ＣＯＰＤ并ＰＡＨ组肺动脉混合静脉血浆ＥＴ－１水平的（８３．９０±１７．１２）ｐｇ／ｍｌ明显高于ＣＯＰＤ非ＰＡＨ组肺动脉混合静脉血浆ＥＴ－１水平（６２．７３±４．４３）ｐｇ／ｍｌ（Ｐ＜０．０５）；肺动脉混合静脉血浆ＥＴ－１水平与肺动脉平均压（ＰＡＰｍ）及肺血管阻力（ＰＶＲ）呈显著的正相关（ｒ＝０．８８，Ｐ＜０．００１；ｒ＝０．０８１，Ｐ＜０．００１），与心输出量（ＣＯ）、氧饱和度（ＳＡＴ％）呈显著的负相关（ｒ＝－０．４７，Ｐ＜０．０５：ｒ＝－０．７９，Ｐ＜０．００１）。提示ＥＴ－１在ＣＯＰＤ并ＰＡＨ的发生发展中起着重要的病理生理学作用。
The hemodynamic parameters of 20 patients with COPD were detected by right-sided floating catheter. The levels of endothelin-1 (ET-1) in the arterial and pulmonary arteries were measured by radioimmunoassay . The results showed that the ET-1 level of body artery (57.00 ± 8.89) pg / ml was less than that of pulmonary artery plasma ET-1 (75.92 ± 17.36) pg / ml (83.90 ± 17.12) pg / ml in PAH group was significantly higher than that in non-PAH group (62.73 ± 4.43) pg / ml in pulmonary artery mixed venous plasma. ml (P <0.05). There was a significant positive correlation between the level of ET-1 in pulmonary artery mixed venous plasma and pulmonary artery mean pressure (PAPm) and pulmonary vascular resistance (PVR) (r = 0.88, = 0.081, P <0.001), and had a significant negative correlation with cardiac output (CO) and oxygen saturation (SAT%) (r = -0.47, P <0.05: r = -0 .79, P <0.001). It is suggested that ET-1 plays an important pathophysiological role in the development of COPD and PAH.