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目的对比观察埃索美拉唑与奥美拉唑治疗胃溃疡的临床疗效。方法将胃溃疡患者128例随机分为观察组和对照组,每组64例。观察组患者给予埃索美拉唑治疗,对照组患者给予奥美拉唑治疗,比较2组患者临床治疗疗效、临床症状评分及不良反应发生情况。结果观察组总有效率为92.19%高于对照组的76.56%,差异有统计学意义(t=3.17,P<0.05)。观察组症状(腹痛、腹胀、反酸、嗳气)评分低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为3.12%低于对照组的12.50%,差异有统计学意义(t=4.62,P<0.05)。结论埃索美拉唑治疗胃溃疡效果理想,且临床不良反应少,用药安全,可作为临床治疗胃溃疡的首选药物。
Objective To compare the clinical effects of esomeprazole and omeprazole in the treatment of gastric ulcer. Methods 128 cases of gastric ulcer patients were randomly divided into observation group and control group, 64 cases in each group. Patients in the observation group were treated with esomeprazole, patients in the control group were treated with omeprazole, and clinical efficacy, clinical symptom scores and adverse reactions were compared between the two groups. Results The total effective rate in observation group was 92.19%, which was significantly higher than 76.56% in control group (t = 3.17, P <0.05). The symptoms of the observation group (abdominal pain, abdominal distension, acid reflux, belching) were lower than those in the control group, with significant differences (P <0.05). The incidence of adverse reactions in the observation group was 3.12% lower than that in the control group (12.50%), the difference was statistically significant (t = 4.62, P <0.05). Conclusion Esomeprazole is effective in treating gastric ulcer and has few clinical adverse reactions and safe administration. It can be used as the drug of choice for clinical treatment of gastric ulcer.