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本文报道单用和合用雷尼替丁(Ran)、西沙必利(Cis)治疗返流性食管炎时,测24小时正常活动下食管内pH及食管内压力的结果。 病人与方法;18例经内镜确诊的返流性食管炎患者中属Ⅰ级孤立糜烂3例、Ⅱ级线型融合糜烂12例、Ⅲ级全周糜烂3例。双盲交叉给予安慰剂、Ran(150mg,bid)或Ran加Cis(20mg,bid)4日。研究前10日起不用其他药物。pH电极送至食管下括约肌口侧5cm处。插入测压导管,其4个传感器分别在顶端(LES上5
This article reports single and combined ranitidine (Ran), cisapride (Cis) regurgitation esophagitis, the determination of normal activity within 24 hours under the esophageal pH and esophageal pressure results. Patients and methods; 18 cases of endoscopic diagnosis of reflux esophagitis in patients with grade Ⅰ isolated erosion in 3 cases, Ⅱ grade fusion erosion in 12 cases, Ⅲ grade erosion in 3 cases. Double-blind crossover was given to placebo, Ran (150 mg, bid) or Ran plus Cis (20 mg, bid) for 4 days. No other drugs have been used since the 10th day of the study. pH electrode sent to the mouth of the lower esophageal sphincter 5cm Department. Insert a pressure-measuring catheter with 4 sensors at the top (5 on the LES