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HLA-Ia(人类白细胞抗原Ⅰ类抗原)在正常肝细胞表面分布极少,但在慢性病毒性肝炎时,其在肝细胞表面的分布呈现一定规律性的变化,而且干扰素的疗效常和这种变化趋势密切相关。本文就HLA-Ia在肝细胞表面增高的机制以及和慢性病毒性肝炎发生发展的关系等方面进行综述。
HLA-Ia (Human Leukocyte Antigen Class I Antigen) is rarely distributed on the surface of normal liver cells. However, the distribution of HLA-Ia on the surface of hepatocytes shows regular changes in chronic viral hepatitis, and the efficacy of interferon is often the same The trend of change is closely related. This article reviews the mechanism of HLA-Ia in hepatocyte surface and its relationship with the occurrence and development of chronic viral hepatitis.