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mi RNA是一类长度约为22 nt的内源性小分子非编码RNA,几乎参与了机体生命活动的所有过程。近年来研究发现,多种肿瘤组织中mi R-489表达下调,其通过转录后抑制靶基因,如HER2、AKT3、SPIN1等的表达,参与肿瘤细胞的增殖、凋亡、侵袭和转移等多种病理过程,并与肿瘤的耐药及发生、发展密切相关。因此,了解mi R-489的表达、调控及其在肿瘤等疾病中的作用及机制,可为其进一步的临床应用奠定基础。本文就mi R-489与恶性肿瘤关系的研究进展进行综述。
MiRNAs are a class of endogenous small non-coding RNAs of about 22 nt in length, which are involved in almost all processes of the body’s life activities. In recent years, it has been found that the expression of mi R-489 is down-regulated in a variety of tumor tissues, which is involved in the proliferation, apoptosis, invasion and metastasis of tumor cells by inhibiting the expression of target genes such as HER2, AKT3 and SPIN1 after transcription Pathological process, and with the drug resistance and occurrence, development is closely related. Therefore, to understand the mi R-489 expression, regulation and its role in tumor and other diseases and mechanisms may lay the foundation for its further clinical application. This article reviews the progress of the research on the relationship between mi R-489 and malignant tumors.