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目的:分析POEMS综合征的临床表现、治疗与预后的关系。方法:采用回顾性分析、整群抽取的研究方法对复旦大学附属华山医院2002年1月至2008年11月出院的POEMS综合征患者病史资料进行统计分析。结果:POEMS综合征多见于50~60岁男性,以周围神经症状为首发,实验室检查多可发现脑脊液中蛋白升高及骨扫描异常。以激素、免疫球蛋白及免疫抑制剂治疗。结论:POEMS综合征系全身性疾病,可予免疫调节或抑制剂治疗。
Objective: To analyze the clinical manifestations, treatment and prognosis of POEMS syndrome. Methods: The retrospective analysis and cluster extraction methods were used to analyze the history data of patients with POEMS syndrome who were discharged from Huashan Hospital of Fudan University from January 2002 to November 2008. Results: POEMS syndrome more common in men 50 to 60 years old, peripheral neurological symptoms as the first episode, laboratory tests and more can be found in cerebrospinal fluid protein and bone scan abnormalities. With hormones, immunoglobulins and immunosuppressive agents. Conclusion: POEMS syndrome is a systemic disease that may be treated with immunomodulatory or inhibitor therapy.