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目的 :对比分析用奥美拉唑和埃索美拉唑治疗消化性溃疡的临床效果。方法 :对2013年2月~2014年2月期间我院收治的68例老年消化性溃疡患者的临床资料进行回顾性研究。我们将这68例患者随机分为观察组和对照组,每组各有34例患者。我院对两组患者均进行抗幽门螺杆菌治疗。在进行抗幽门螺杆菌治疗的基础上,我院给观察组患者使用埃索美拉唑进行治疗,给对照组患者使用奥美拉唑进行治疗。治疗结束后,比较两组患者治疗的效果、幽门螺杆菌的清除率和发生不良反应的情况。结果 :观察组患者治疗的总有效率为91.5%,对照组患者治疗的总有效率为67.65%。观察组患者治疗的总有效率明显高于对照组患者,二者相比差异具有显著性(P﹤0.05)。观察组患者幽门螺杆菌的清除率为85.3%,对照组患者幽门螺杆菌的清除率为73.5%。观察组患者幽门螺杆菌的清除率明显高于对照组患者,二者相比差异具有显著性(P﹤0.05)。两组患者发生不良反应的几率均为4.41%,二者相比差异无显著性(P﹥0.05)。结论 :与奥美拉唑相比,用埃索美拉唑治疗消化性溃疡的效果更好,清除幽门螺杆菌的几率更高,而且比较安全。因此,埃索美拉唑可作为治疗消化性溃疡的优选药物。
Objective: To compare the clinical effects of omeprazole and esomeprazole in the treatment of peptic ulcer. Methods: The clinical data of 68 elderly patients with peptic ulcer admitted to our hospital from February 2013 to February 2014 were retrospectively studied. We divided the 68 patients into observation and control groups randomly, each with 34 patients in each group. Two groups of patients in our hospital were anti-Helicobacter pylori treatment. In the anti-Helicobacter pylori treatment on the basis of our hospital to the observation group patients with esomeprazole for treatment, the control group of patients treated with omeprazole. After treatment, the efficacy of treatment, the clearance rate of Helicobacter pylori and the adverse reactions were compared between the two groups. Results: The total effective rate was 91.5% in the observation group and 67.65% in the control group. The total effective rate of observation group was significantly higher than that of the control group, the difference was significant (P <0.05). In the observation group, the clearance rate of Helicobacter pylori was 85.3% and that of the control group was 73.5%. The clearance rate of Helicobacter pylori in the observation group was significantly higher than that in the control group, the difference was significant (P <0.05). The incidence of adverse reactions in both groups were 4.41%, there was no significant difference between the two groups (P> 0.05). CONCLUSIONS: Compared with omeprazole, esomeprazole is more effective in treating peptic ulcer and is more likely to be cleared of Helicobacter pylori and is safer. Therefore, esomeprazole can be used as the preferred drug for the treatment of peptic ulcer.