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论述了pH值对鸟苷发酵的影响。采用摇瓶和FUS50全自动控制发酵罐,以枯草芽孢杆菌Bacillussubtilis A066为供试菌株,在不同pH条件下研究鸟苷发酵工艺,经过优化pH控制可使鸟苷产率由原来生产最高水平20g/l左右提高到30g/l,比原来提高了10g/l,过程稳定并能够重复多批次。从而大幅度降低生产成本和提高了设备使用效率。
The effect of pH on guanosine fermentation was discussed. Using shake flask and FUS50 automatic control fermenter, Bacillus subtilis Bacillussubtilis A066 as test strain, under different pH conditions to study guanosine fermentation process, optimized pH control can guanosine yield from the original production of the highest level of 20g / l or so increased to 30g / l, increased by 10g / l than the original, the process is stable and can repeat multiple batches. Thus greatly reducing production costs and improve equipment efficiency.