【摘 要】
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The basis of life-long spermatogenesis is spermatogonial stem cells(SSCs)located at the basal membrane of the seminiferous tubules in the testis.After several rounds of proliferation and spermatogonial differentiation,the male germ cells will eventually u
【机 构】
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Center for Reproductive Medicine,Reproductive Biology Laboratory,Amsterdam Reproduction and Developm
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The basis of life-long spermatogenesis is spermatogonial stem cells(SSCs)located at the basal membrane of the seminiferous tubules in the testis.After several rounds of proliferation and spermatogonial differentiation,the male germ cells will eventually undergo meiosis to form haploid spermatids.Disturbance of the molecular regulation of spermatogenesis can lead to spermatogenic arrest,in humans often during meiosis,1,2 and subsequent azoospermia.Unfortunately,no treatment option enabling conception of a genetically own child is currently available for men suffering from spermatogenic arrest before spermatids are formed.
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