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高血压左室重构是通过一系列复杂的分子和细胞间相互作用而导致心脏结构、功能变化的结果 ,表现为心肌细胞的肥大和凋亡、非心肌细胞的增殖、细胞外基质量和组成的改变等。左室重构在一定程度上是心脏对后负荷增加、神经内分泌激活的代偿反应 ,同时也是许多心血管病事件的独立
Hypertension Left ventricular remodeling is the result of changes in cardiac structure and function through a series of complex intermolecular and intercellular interactions characterized by hypertrophy and apoptosis of cardiomyocytes, proliferation of non-cardiomyocytes, mass and composition of extracellular matrix Change and so on. Left ventricular remodeling is to some extent the heart’s compensatory response to increased postload and neuroendocrine activation and is also an independent event for many cardiovascular events