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目的 :研究原发性肺癌中基质金属蛋白酶 - 2 (MMP - 2 )的表达与肺癌不同病理类型、TNM分期的关系及其预后的意义。方法 :用已知阳性的乳腺癌组织切片作为阳性对照 ,选择免疫组织化学染色方法对 65例肺癌组织中MMP - 2的表达水平进行检测。结果 :MMP - 2在所有肺癌组织中均有表达。腺癌组和腺鳞癌组中MMP - 2的表达水平显著高于鳞癌组 (P <0 .0 1 ) ,但在腺癌组与腺鳞癌组中的表达差异不明显 (P =0 .2 33)。MMP - 2的表达水平随TNM分期增加而增加 ,其中Ⅰ期与Ⅲa期、Ⅰ期与Ⅲb期、Ⅱ期与Ⅲb期之间相比有显著性差异 (P <0 .0 1 ) ;Cox ,s-比例风险模型多因素分析提示患者的生存期随着MMP - 2表达的增高而降低。结论 :肺癌组织中MMP - 2的表达与肺癌的TNM分期和预后有关 ,提示MMP - 2的表达水平可能是评估肺癌预后的指标。
Objective: To investigate the relationship between the expression of matrix metalloproteinase - 2 (MMP - 2) and the different pathological types and TNM stage in primary lung cancer and its prognostic significance. Methods: The positive breast cancer tissue sections were used as positive control, and the expression of MMP - 2 in 65 cases of lung cancer tissues was detected by immunohistochemical staining. Results: MMP - 2 was expressed in all lung cancer tissues. The expression of MMP - 2 in adenocarcinoma and adenosquamous carcinoma was significantly higher than that in squamous cell carcinoma (P <0.01), but not in adenocarcinoma and adenosquamous carcinoma (P = 0 .2 33). The expression of MMP - 2 increased with the increase of TNM staging, including Ⅰ, Ⅲa, Ⅰ, Ⅲb, Ⅱ and Ⅲb (P <0.01); Cox, Multivariate analysis of s - proportional hazard model suggested that patients’ survival decreased with the increase of MMP - 2 expression. Conclusion: The expression of MMP - 2 in lung cancer is correlated with the TNM stage and prognosis of lung cancer, suggesting that the expression of MMP - 2 may be an index to evaluate the prognosis of lung cancer.