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埃坡霉素是一类新型抗微管蛋白解聚类化合物,在体内外均有强大广谱的抗肿瘤活性,且对紫杉醇耐药的肿瘤有效。本文综述多种埃坡霉素类药物近年来的抗肿瘤作用及药动学研究进展。
Epothilones are a new class of anti-tubulin depolymerizing compounds that have potent broad-spectrum antitumor activity both in vitro and in vivo and are effective against paclitaxel-resistant tumors. This review summarizes the antitumor effects and pharmacokinetics of various epothilones in recent years.