The purpose of this project is to control the pollution of dust, which occurred in a typical lead-zinc mine. Two kinds of surfactants and water glass were chosen as the wetting agents to study the behaviours of suppressing the dust. The performances of the wetting agents of various sizes and water content of dust and their compositions among different weting agents were investigated. Firstly, the chemical compounds, dispersity, water content, bulk density and other relevant physico-chemical properties of the choiced dust of lead-zinc ore were mensurated. A great number of down-ward penetrating tests were conducted to different partical sizes of dust and to analyze the dust wetting behaviour respectively. The optimal compositions of wetting agents were obtained in accordance with different water contents and partical sizes of the dust after analyzing and statisting the achieved experimental data. The data show that the efficiency of chemical dust suppression of weting agents is much better than that of water. The results of the research work prove that the partical size and the water content of the dust are very important factors to the dust suppression. The results are also proved validly by the dropping experiment, which takes the penetrating diameter and penetrating time as the major factors. The superfine dust is much more difficult to be wetted. Since increasing the water content of dust is the best approach to control it, the choice of wetting agents for improving dispensation is significant.