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近年曾对包括恶性肿瘤在内的各种疾病患者血清铜(SCu)、锌(SZn)水平进行过深入研究,而对其代谢重要性和生物学作用已有了较好的了解,并新用了更好的分析方法。已确定在此类疾病的活动期,SCu升高及/或SZn降低系非特异性反应。主要研究过血液恶性疾病(如白血病、淋巴瘤)的SZn、SCu水平及其临床用途。对少数几种实体肿瘤(如支气管癌、肉瘤、消化道癌)曾报告过低SZn及高SCu,但对妇科恶性肿瘤几无报道。本文目的在于测定妇科良及恶性肿瘤患者SCu及SZn水平,以确定SCu/SZn比值的诊断价值及与恶性肿瘤分期的相关关系。受试者为73例首次住院的可疑妇科肿瘤患者。取静脉血,血清经三氯醋酸处理,离心得上清液用原子吸收分光光度法测SCu、SZn浓度,测定26
In recent years, the levels of serum copper (SCu) and zinc (SZn) in patients with various diseases including malignant tumors have been intensively studied, and their metabolic importance and biological effects have been well understood and newly used A better analytical method. It has been established that an increase in SCu and / or a decrease in SZn in the active phase of such diseases are nonspecific reactions. The main study of hematological malignancies (such as leukemia, lymphoma) SZn, SCu levels and their clinical use. On a small number of solid tumors (such as bronchial carcinoma, sarcoma, gastrointestinal cancer) have reported low SZn and high SCu, but few reports of gynecologic malignancies. The purpose of this article is to determine the SCu and SZn levels in patients with benign and malignant gynecological diseases in order to determine the diagnostic value of SCu / SZn ratio and the correlation with the staging of malignant tumors. Subjects were 73 first-time hospitalized patients with suspected gynecologic cancer. Venous blood was taken and the serum was treated with trichloroacetic acid. The supernatant was centrifuged to determine the concentration of SCu and SZn by atomic absorption spectrophotometry. The concentration of 26