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目的观察普罗帕酮联合美托洛尔治疗小儿心律失常的临床疗效。方法选取2014年5月—2016年5月恩施土家族苗族自治州中心医院收治的心律失常患儿80例,采用随机数字表法分为对照组和观察组,每组40例。对照组患儿给予普罗帕酮治疗,观察组患儿给予普罗帕酮联合美托洛尔治疗。比较两组患儿临床疗效,治疗后房性期前收缩、室性期前收缩、短阵房性心动过速、短阵室性心动过速发作次数及不良反应发生情况。结果观察组患儿临床疗效优于对照组(P<0.05)。观察组患儿治疗后房性期前收缩、室性期前收缩、短阵房性心动过速、短阵室性心动过速发作次数均少于对照组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论普罗帕酮联合美托洛尔治疗小儿心律失常的临床疗效确切,可有效减少房性期前收缩、室性期前收缩、短阵房性心动过速、短阵室性心动过速发作次数,且不良反应较少。
Objective To observe the clinical efficacy of propafenone and metoprolol in the treatment of children with arrhythmia. Methods Eighty children with arrhythmia admitted from May 2014 to May 2016 in Enshi Tujia and Miao Autonomous Prefecture Central Hospital were randomly divided into control group and observation group with 40 cases in each group. Propafenone was given to children in the control group and propafenone combined with metoprolol in the observation group. The clinical efficacy, the atrial contraction, the ventricular contraction, the short atrial tachycardia, the number of episodes of bradycardia and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of observation group was better than that of control group (P <0.05). The number of episodes of atrial premature rupture, ventricular premature ventricular contraction, short atrial tachycardia and short bursts of ventricular tachycardia in observation group were less than those in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Propafenone combined with metoprolol in the treatment of children with arrhythmia clinical effect is exact, can effectively reduce atrial contraction, ventricular contraction, short atrial tachycardia, paroxysmal tachycardia episodes , And less adverse reactions.