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应用生化法和放射免疫分析法分别检测了不吸烟的１０例特发性肺纤维化（ＩＰＦ）患者和６例正常对照者支气管肺泡灌洗液（ＢＡＬＦ）和血中谷胱甘肽（ＧＳＨ）及透明质酸（ＨＡ）水平，以判断氧自由基代谢异常与肺纤维化的关系。结果：①ＩＰＦ患者ＢＡＬＦ中ＧＳＨ水平明显低于正常对照组（Ｐ＜０．０５）；②ＩＰＦ患者ＢＡＬＦ中ＨＡ水平明显高于正常对照组（Ｐ＜０．０５），且与嗜中性粒细胞计数呈显著正相关（ｒ＝０．６３４，Ｐ＜０．０５）；③血中ＧＳＨ和ＨＡ含量在病变组和对照组无明显差别。说明肺组织局部ＧＳＨ降低对肺纤维化形成有一定作用，ＢＡＬＦ中ＨＡ测定对判定肺泡炎程度有一定意义。
Biochemical and radioimmunoassay methods were used to detect bronchoalveolar lavage fluid (BALF) and glutathione (GSH) in 10 patients with idiopathic pulmonary fibrosis (IPF) and 6 normal controls Hyaluronic acid (HA) levels to determine the relationship between oxygen free radical metabolism and pulmonary fibrosis. Results: ① The level of GSH in BALF of patients with IPF was significantly lower than that of the normal control (P <0.05). ② The level of HA in BALF of patients with IPF was significantly higher than that of the normal control (P <0.05), and the level of neutrophil (R = 0.634, P <0.05). ③ The content of GSH and HA in blood had no significant difference between the lesion group and the control group. This shows that the reduction of pulmonary GSH has a certain effect on the formation of pulmonary fibrosis, and the determination of BAL in HA to determine the degree of alveolitis has some significance.