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引起我国肾综合征出血热(HFRS)流行的病毒主要是姬鼠型(Ⅰ型)和家鼠型(Ⅱ型)两个血清型,我国绝大多数疫区为混合型疫区.在混合型疫区如何选择合适疫苗进行接种,是目前面临的问题.动物实验表明,应用L_99株制备的HFRS疫苗接种动物后,再应用Ⅰ、Ⅱ型病毒进行攻击,均可产生明显保护.为探讨L_99株疫苗的流行病学效果,1995年在莒南县进行了人群免疫效果观察,报告如下:1 材料与方法1.1 疫苗 长春生物制品所研制的Ⅱ型HFRS疫
The viruses that cause the epidemic of HFRS in our country are mainly two serotypes of Apodemus (type I) and domestic mouse (type II), and most of the epidemic areas in China are mixed type epidemic areas. How to choose appropriate vaccines for vaccination in the epidemic area is the current problem.The animal experiments show that application of HFRS vaccine L_99 strains vaccinated animals, and then use type I and type II viruses attack, can produce significant protection .To explore the L_99 strain Vaccine epidemiological effects in 1995 in Taonan County conducted a population-based immunosuppression, the report is as follows: 1 Materials and methods 1.1 Vaccine Changchun biological products developed by the type HFRS epidemic