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目的 探讨载脂蛋白B(apoB)基因变异与颈动脉粥样硬化的关系。 方法 对 5 6例颈动脉粥样硬化患者及 5 0名非颈动脉粥样硬化者的apoB基因的XbaI位点的多态性进行了研究。检测两组颈动脉内膜—中膜厚度 (IMT)及斑块指数 (PI)。结果 观察组X+ 等位基因频率明显高于对照组。观察组含X+ 等位基因型者总胆固醇、低密度脂蛋白 胆固醇、apoB水平显著高于X-X-基因型者 ;观察组含X+ 基因型者IMT比X-X-基因型明显增厚且含X+ 等位基因型者颈动脉PI比X-X-基因型亚组明显增大。结论 apoB基因XbaI的X+ 等位基因与颈动脉粥样硬化有一定关联
Objective To investigate the relationship between apoB gene mutation and carotid atherosclerosis. Methods The XbaI polymorphism of apoB gene in 56 patients with carotid atherosclerosis and 50 non-carotid atherosclerosis was studied. The intima - media thickness (IMT) and plaque index (PI) of the two groups were detected. Results The frequency of X + allele in observation group was significantly higher than that in control group. The levels of total cholesterol, LDL-C and apoB in X + allele of observation group were significantly higher than that of XX-genotype. IMT of X + genotype in observation group was significantly thicker than that in XX- The genotype of carotid artery PI was significantly higher than the subgenotype of XX-genotype. Conclusion Xpo allele of apoB gene is associated with carotid atherosclerosis