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内皮素是迄今所知效应最强、持续时间最久的血管收缩肽，并有促平滑肌细胞增殖的作用，在多种疾病中其浓度明显升高，并随着病情的进展而变化，因此它可能是一种内源性致病因素[1]。而TXA2和PGI2是机体调节血小板功能、保护血管的重要因子，由血小板释放的TXA2具有强烈的血小板
Endothelin is the most potent and long-lasting vasoconstrictor known to date and has the effect of promoting the proliferation of smooth muscle cells. Its concentration is obviously increased in many diseases and changes with the progression of the disease, so it May be an endogenous risk factors [1]. TXA2 and PGI2 are important factors that regulate platelet function and protect blood vessels. TXA2 released from platelets has a strong platelet