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支配粘膜表面免疫应答的机理尚末充分明确。用可溶性蛋白质作肠道外免疫能改变以后在粘膜表面给与相同抗原时的局部免疫应答。本文的目的是研究特异性血清抗体是否抑制粘膜免疫应答及其机理。免疫抗原为霍乱毒素或霍乱类毒素,动物为纯Wistar-Lewis品系大鼠,用计数肠壁基底层及胸导管淋巴细胞中的含抗毒素细胞(antitoxincontaining cell,ACC)数测定免疫应答情况。在十二指肠内给与毒素引发(Prime,
The mechanism governing the mucosal surface immune response is not fully understood. Parenteral immunization with soluble proteins can alter the local immune response when mucosal surfaces are given the same antigen. The purpose of this article is to investigate whether specific serum antibodies inhibit mucosal immune responses and their mechanisms. The immune antigen was cholera toxin or cholera toxoid, and the animals were pure Wistar-Lewis rats. The immune response was measured by counting the number of antitoxin-containing cells (ACC) in the basal layer of the intestinal wall and in the thoracic ductal lymphocytes. Toxin-induced in the duodenum (Prime,