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目的了解珠海口岸出入境人员乙型肝炎病毒感染情况及肝功能异常情况,为有效控制传染病经口岸传播提供科学依据。方法对2014年8月至2015年2月珠海口岸出入境人员进行乙肝抗原(HBs Ag、HBe Ag)的ELISA筛查,同时对丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)及碱性磷酸酶(ALP)进行检测,并对检测结果进行统计分析。结果共检出入境人员14 343例,乙肝表面抗原HBs Ag阳性有1 657人(珠海户籍413人,流动人口1 244人),总体感染率为11.6%。HBs Ag合并HBe Ag抗原双阳性有286人,双阳性率为1.99%(286/14 343),流动人口HBs Ag、HBe Ag双阳性占比(243/1 244)明显高于珠海户籍人员(43/413)(P=0.000)。流动人口ALT、AST、GGT异常率高于珠海户籍人口;男性ALT异常率明显高于女性(P=0.045)。结论珠海口岸出入境人员乙肝总体感染率和转氨酶异常率相对较高,应加强对出入境人员中HBs Ag合并e抗原阳性且转氨酶异常者的宣教和控制。
Objective To understand the status of Hepatitis B virus (HBV) infection and abnormal liver function in entry and exit personnel in Zhuhai Port, and provide a scientific basis for effectively controlling the spread of infectious diseases through ports. Methods The screening of hepatitis B antigens (HBs Ag, HBe Ag) was performed in Zhuhai port from August 2014 to February 2015. Meanwhile, the effects of alanine aminotransferase (ALT), aspartate aminotransferase AST, GGT and ALP, and the results were analyzed statistically. Results A total of 14 343 immigrants were found. There were 1 657 HBsAg positive patients (413 in Zhuhai and 1 244 in floating population). The overall infection rate was 11.6%. There were 286 pairs of positive HBsAg and HBeAg antigens, with a double positive rate of 1.99% (286/14 343). The double positive rate of HBsAg and HBeAg in the floating population (243/1 244) was significantly higher than that of the Zhuhai household /413)(P=0.000). The abnormal rate of ALT, AST and GGT in floating population was higher than that in Zhuhai. The abnormal rate of ALT in male was significantly higher than that in female (P = 0.045). Conclusion The overall infection rate of hepatitis B and the abnormal rate of aminotransferase in entry and exit personnel in Zhuhai Port are relatively high. The mission and control of HBsAg-positive e antigen and transaminase abnormality should be strengthened in entry-exit personnel.