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当心房扩张时如充血性心力衰竭、房颤及房性心动过速时,血浆心房利钠肽(ANP)浓度增高。心肌梗塞的急性缺血伴有心室功能的损害,扩张的心房将释放出较多的ANP。作者测定4例在疼痛发作2小时内急性前壁心肌梗塞病人的血浆ANP浓度。其中3例应用全身纤溶治疗;另1例则不用此方法。每30分钟从肘前静脉取血后马上分离血浆,在放免测定前于-20℃冰冻保存。 结果所有4例病人血浆ANP浓度正常或轻度升高,在疼痛发作的最初3～8小时ANP水平降低,尽管此时临床检查或胸部X线检查有心衰的征象。3例病人出院后再次检查则发现ANP浓度增高。
When atrial expansion, such as congestive heart failure, atrial fibrillation and atrial tachycardia, plasma atrial natriuretic peptide (ANP) concentration increased. Acute ischemic myocardial infarction associated with ventricular dysfunction, dilatation of the atrium will release more ANP. The authors measured plasma ANP concentrations in 4 patients with acute anterior myocardial infarction within 2 hours of onset of pain. Three cases of systemic fibrinolysis treatment; the other case does not need this method. Plasma was taken immediately after blood was taken from the antecubital vein every 30 minutes and stored frozen at -20 ° C before radioimmunoassay. Results All 4 patients had normal or mild plasma ANP levels and decreased ANP levels during the first 3 to 8 hours of the episode of pain, although clinical examination or chest X-ray showed signs of heart failure at this time. Three patients were re-examined after discharge and found that ANP concentration increased.