应用~(51)Cr标记人的多发性骨髓瘤(MM)细胞系U266、XG-7,着重研究了细胞因子对人MM系U266、XG-7——内皮细胞间粘附的调控作用及其对细胞表面粘附分子表达、细胞因子分泌的影响。主要结果表明:(1)IL-6及其IL-6Rgp130相关性生长因子(GM-CSF等)不仅是人MM细胞体内、外的生长因子,而且可以提高MM细胞——内皮细胞间的粘 The human multiple myeloma (MM) cell lines U266 and XG-7 were labeled with ~ (51) Cr, and the regulatory effect of cytokines on human MM line U266 and XG-7-endothelial cell adhesion On cell surface adhesion molecule expression, cytokine secretion. The main results showed that: (1) IL-6 and IL-6Rgp130-associated growth factor (GM-CSF) are not only the growth factors of human MM cells both in vitro and in vivo, but also enhance the adhesion between MM cells and endothelial cells