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1-磷酸鞘氨醇(sphingosine1-phosphate,S1P)是细胞膜鞘磷脂的代谢产物之一,在多种恶性肿瘤形成、转化和进展过程中发挥重要作用,能够调节肿瘤细胞增殖、凋亡及血管的新生。S1P对恶性肿瘤的生物学行为因细胞类型及受体(sphingosine1-phosphate receptor,S1PR)表达不同而不同,在结肠癌和卵巢癌细胞中S1P通过S1PR1/S1PR3促进肿瘤细胞的生长,而在黑素瘤细胞中则通过S1PR2抑制肿瘤细胞的生长,不同受体介导的下游信号通路也不尽相同。因此,本文就S1P对不同肿瘤细胞生物学行为的影响及通过不同受体所介导的信号通路作一综述。
Sphingosine-1-phosphate (S1P), one of the metabolites of sphingomyelin, plays an important role in the formation, transformation and progression of various malignant tumors and regulates tumor cell proliferation, apoptosis and angiogenesis newborn. S1P biological behavior of malignant tumors due to the cell type and the receptor (sPRingosine1-phosphate receptor, S1PR) expression varies in S1P colon cancer and ovarian cancer cells by S1PR1 / S1PR3 promote tumor cell growth, while in melanin S1PR2 tumor cells in tumor cells by inhibiting the growth of different receptor-mediated downstream signaling pathways are not the same. Therefore, this article on S1P on the biological behavior of different tumor cells and through different receptor-mediated signaling pathway are reviewed.