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本文测定了结肠癌患者手术前后血清白细胞介素一12（IL－12）和可溶性白细胞介素-2受体（SIL－2R）的表达水平。结果表明，结肠癌患者术前和术后血清见IL-12表达低于正常对照组，sIL－2R表达明显高于正常对照组。术前和术后血清IL－12及sIL－2R表达无显著性差异。初步研究提示，对结肠癌患者采用免疫治疗，以IL－12较IL－2更为合适。
This study measured the expression of serum IL-12 and soluble interleukin-2 receptor (SIL-2R) in patients with colon cancer before and after surgery. The results showed that IL-12 expression was lower in preoperative and postoperative serum samples of patients with colon cancer than in the normal control group, and the expression of sIL-2R was significantly higher than that in the normal control group. There was no significant difference in serum IL-12 and sIL-2R expression before and after surgery. Preliminary studies suggest that immunotherapy of colon cancer patients is more appropriate for IL-12 than for IL-2.