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目的分析四川省2007～2008年麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)强化免疫活动的预防接种异常反应发生特征,探讨MV强化免疫活动的安全性及减少预防接种异常反应的措施。方法采用描述性方法对相关指标进行流行病学分析。结果四川省2007～2008年MV强化免疫活动共报告59例预防接种异常反应,发生率为4.13/100万剂次;男性多于女性,各年龄组发生率的差异无显著的统计学意义(x2=0.53,P>0.05);接种后<2d出现反应的占3/4;临床损害以过敏性反应多见;绝大多数病例预后良好。结论MV强化免疫活动的预防接种异常反应发生率低,各年龄组儿童在接种MV后<2d是监测的重点。应加强监测,提高预防接种异常反应的预防和处理水平。
Objective To analyze the characteristics of vaccination abnormalities during measles immunization with Measles Attenuated Live Vaccine (MV) from 2007 to 2008 in Sichuan province, and to explore the safety of the immunization campaigns and the measures to reduce the abnormal response to vaccination. Methods The descriptive method was used to carry out epidemiological analysis of related indicators. Results A total of 59 cases of vaccination anomalous reactions were reported in Sichuan province during 2007-2008 MV episodes. The incidence was 4.13 / 1 million doses. There were more males than females, with no significant difference in the incidence of each age group (x2 = 0.53, P> 0.05) .3% of the patients showed reaction after 2 days of inoculation. The clinical damage was more common in allergic reactions. The prognosis of the most cases was good. Conclusion The incidence of abnormal vaccination response to MV-intensive immunization activities is low. Children of all age groups <2 days after MV vaccination are the focus of monitoring. Monitoring should be strengthened to raise the level of prevention and treatment of abnormal responses to vaccination.