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金丝雀痘(CP)病毒和禽痘(FP)病毒不能在非鸟类细胞中复制,它们已被用作活载体,携带具有免疫抑制区(IS)的全长HIV-1SF2包膜基因或者缺失IS区的包膜基因.作者用含完整包膜基因的CPIS~+和FPIS~+及含缺失IS的包膜基因的CPIS~-和FPIS~-重组病毒及非重组的野生型CPwt或FPwt免疫家兔,观察体液及细胞免疫应答.用CPIS~-、FPIS~+及CPIS~-、FPIS~-及野生型CPwt或FPwt对家兔进行基础免疫和4次加强免疫后.以ELISA、免疫印迹试验、淋巴细胞增殖试验、病毒中和试验检测家兔体内体液及细胞免疫应答.
The canarypox (CP) virus and the fowlpox (FP) virus, which can not replicate in non-avian cells, have been used as live vectors carrying the full-length HIV-1 SF2 envelope gene with immunosuppressive region (IS) or Deletion of IS envelope genes.We used CPIS ~ + and FPIS ~ + with complete envelope genes and CPIS ~ - and FPIS ~ - recombinant viruses with envelope genes lacking IS and non-recombinant wild-type CPwt or FPwt The rabbits were immunized to observe the humoral and cellular immune responses, and the rabbits were immunized with CPIS, FPIS ~ +, CPIS ~ -, FPIS ~ - and wild type CPwt or FPwt, Western blotting, lymphocyte proliferation test and virus neutralization test were used to detect humoral and cellular immune responses in rabbits.