目的对比利福喷丁与利福平治疗肺结核的临床效果。方法将肺结核患者124例按入院顺序分为研究组(利福喷丁治疗)和对照组(利福平治疗),每组62例。对比2组空洞闭合率、痰菌转阴率、病灶吸收情况和不良反应发生情况。结果研究组空洞闭合率、痰菌转阴率、病灶吸收率均高于对照组,不良反应总发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论利福喷丁治疗肺结核效果显著,安全性高,值得临床推广应用。 Objective To compare the clinical effects of rifapentine and rifampin in the treatment of pulmonary tuberculosis. Methods 124 cases of tuberculosis patients were divided into research group (rifapentine treatment group) and control group (rifampicin treatment group) according to the order of admission, with 62 cases in each group. Compare the two groups of cavity closure rate, sputum negative rate, absorption of lesions and adverse reactions. Results In the study group, the void closure rate, sputum negative conversion rate, and lesion absorption rate were all higher than those in the control group. The overall incidence of adverse reactions was significantly lower than that of the control group (P <0.05). Conclusion rifapentine treatment of tuberculosis significant effect, high safety, worthy of clinical application.