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目的:了解甘肃省细菌性痢疾发病规律,及志贺菌的病原学和药敏特点,为细菌性痢疾的防制提供科学依据。方法:对甘肃省报告和监测的细菌性痢疾病例进行流行病学分析,按《全国细菌性痢疾监测方案》提供的方法对菌株进行检测。结果:2005年-2009年细菌性痢疾年均发病率63.87/10万,0岁(婴儿)组年均发病率最高469.64/10万,但检测阳性率较其他年龄组最低12.41%。对571株阳性志贺菌株分型,福氏志贺菌339株,宋内氏230株。阿莫西林、氨苄西林、四环素、利福平的多重耐药率94.62%。结论:全省2005年-2009年细菌性痢疾发病呈平缓下降趋势,但流行菌型有所变化,宋内氏菌比例增加,婴儿组病例诊断准确性不高,志贺菌耐药性日趋严重,对菌痢的防控工作提出了新的挑战。
Objective: To understand the pathogenesis of bacterial dysentery in Gansu Province, and Shigella etiology and susceptibility characteristics for the prevention of bacterial dysentery to provide a scientific basis. Methods: The epidemiological analysis of bacterial dysentery reported and monitored in Gansu Province was carried out according to the method provided in National Bacterial Dysentery Surveillance Program. Results: The average annual incidence of bacterial dysentery in 2005-2009 was 63.87 / 100 000, the highest incidence was 469.64 / 100 000 in the 0-year-old (infants) group, but the positive rate was 12.41% lower than other age groups. 571 Strain positive Shigella typing, Shigella flexneri 339, Song Neishi 230. Amoxicillin, ampicillin, tetracycline, rifampin multi-drug resistance rate of 94.62%. Conclusion: The incidence of bacillary dysentery decreased gently from 2005 to 2009 in the whole province, but the prevalence of bacillary dysentery changed, the proportion of S.eliculans increased, the accuracy of diagnosis in infant group was not high, and the resistance of Shigella was more and more serious , The prevention and control of bacillary dysentery put forward new challenges.