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本文用E-cd单克隆抗体对57例膀胱移行细胞癌及7例正常粘膜的石蜡标本进行了免疫组化研究。结果E-cd在不同分期及分级膀胱癌中的表达均有显著性差异(P<0.05)。E-cd在复发与未复发组膀胱癌中表达亦有显著性差异(P<0.01)。随访发现E-cd表达与患者生存率有显著关系(P<0.01)。提示E-cd表达可以作为判断膀胱癌恶性程度及复发和预后的生物学指标。
In this paper, E-cd monoclonal antibody on 57 cases of transitional cell carcinoma of the bladder and 7 cases of normal mucosa immunohistochemical study of paraffin specimens. Results The expression of E-cd in different stage and grade of bladder cancer had significant difference (P <0.05). The expression of E-cd in bladder cancer was also significantly different between recurrent and non-recurrent group (P <0.01). Follow-up found E-cd expression and patient survival rate was significantly related (P <0.01). E-cd expression tips can be used as a biological indicator to determine the degree of malignancy and recurrence and prognosis of bladder cancer.