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目的 研究婴幼儿初次下呼吸道感染患者中血清IgG亚类变化情况。 方法 随机抽取 185例初次下呼吸道感染病儿 ,用ELISA法检测血清IgG及IgG亚类浓度。并与该地区健康小儿血清浓度进行比较。以低于参考值下限 ( x - 1.96s)者为IgG或IgG亚类缺陷 ,而高于 ( x +1.96s)者视为IgG亚类增高。 结果 185例共检出 4 3例IgG缺陷 ,均有IgG亚类缺陷 ,而余下的 14 2例IgG正常者 ,发现IgG亚类缺陷 12 0例 ,检出率高达84 .5 %。其中 0～ 3月 4项、3项缺陷合计 2 9例 ,占该年龄段缺陷总数的 85 .3% ,在各年龄段中为最高比例。而IgG亚类缺陷中以IgG3缺陷最高 ,占 4 7.6 %。结论 婴幼儿初次下呼吸道感染伴有IgG亚类缺陷。年龄越小 ,越易出现IgG亚类联合缺陷。因而在检测Ig时 ,除注意总IgG外 ,还应注意IgG亚类水平。
Objective To study the changes of serum IgG subclasses in infants with initial lower respiratory tract infection. Methods A total of 185 children with primary lower respiratory tract infection were randomly selected and serum IgG and IgG subclasses were detected by ELISA. And healthy children in the region compared serum concentrations. IgG or IgG subclass deficiencies were below the lower reference limit (x - 1.96s), while those above (x + 1.96s) were considered IgG subclasses to be elevated. Results Of the 185 cases, 43 cases of IgG deficiency were detected, all of which had IgG subclass deficiency. The remaining 14 2 cases of IgG were normal, and the IgG subclass defect was found in 120 cases with a detection rate as high as 84.5%. Of which 0 to March 4, 3 defects total 29 cases, accounting for 85.3% of the total number of defects in this age group, in all age groups for the highest proportion. IgG3 defects in the highest IgG3 defect, accounting for 4 7.6%. Conclusion Infants with primary lower respiratory tract infection have IgG subclass deficiencies. The younger, the more prone to IgG subclasses combined defects. Therefore, in the detection of Ig, in addition to pay attention to the total IgG, but also pay attention to the level of IgG subclasses.