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肾缺血再灌注损伤是指在肾组织缺血基础上恢复血液灌注后肾脏功能不能得到恢复,并发生一系列病理生理反应。目前尚无治疗肾缺血再灌注损伤的特效药物。文章根据肾缺血再灌注损伤的病理生理特点,综合国内外最新研究结果,综述包括细胞凋亡蛋白酶抑制药、P-选择素拮抗药、抗氧化剂等治疗肾缺血再灌注损伤药物的研究进展。为肾缺血再灌注损伤的有效干预提供参考。
Renal ischemia-reperfusion injury refers to renal function can not be restored after hemoperfusion is resumed on the basis of renal ischemia, and a series of pathophysiological reactions occur. There is no specific treatment for renal ischemia-reperfusion injury. According to the pathophysiological characteristics of renal ischemia-reperfusion injury and the latest research results at home and abroad, the progress of renal ischemia-reperfusion injury including apoptosis protease inhibitors, P-selectin antagonists and antioxidants is reviewed . Provide a reference for effective intervention of renal ischemia-reperfusion injury.