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目的 :探讨梗阻性黄疸 (梗黄 )肾损害及丹参保护作用机制。方法 :将 36只大鼠随机分为对照组、胆总管结扎组和丹参治疗组 ,以结扎胆总管方法建立梗黄肾损害鼠模型 ,丹参治疗组每日每只腹腔内注射 2g丹参注射液。 3组大鼠分别于术后第 7、14、2 1和 2 8天活杀 ,检测血清和肾组织中丙二醛 (MDA)及超氧化物歧化酶 (SOD)的变化 ,并观察肾功能和肾病理组织学改变。结果 :与非治疗组相比 ,丹参治疗组的血清及肾组织中SOD活性显著升高 ,而MDA则显著下降 (P <0 .0 5 ) ,肾功能和肾病理组织改变也较轻。结论 :氧自由基所引发的脂质过氧化作用是梗黄鼠肾损害发病过程中的重要因素之一 ,应用丹参可明显降低肾脏病理组织损害程度。
Objective: To investigate the renal damage of obstructive jaundice (stem yellow) and the protective mechanism of Salvia Miltiorrhiza. Methods: Thirty-six rats were randomly divided into control group, common bile duct ligation group and Salvia miltiorrhiza treatment group. The rat model with stem and kidney damage was established by ligation of the common bile duct. The Salvia miltiorrhiza group received intraperitoneal injection of 2g salvia miltiorrhiza injection daily. The rats in the three groups were sacrificed on the 7th, 14th, 21st, and 28th day after operation. The changes of malondialdehyde (MDA) and superoxide dismutase (SOD) in the serum and kidney tissues were detected. And renal histopathology changes. Results: Compared with non-treatment group, the activity of SOD in serum and kidney tissue of Salvia miltiorrhiza group was significantly increased, while MDA was significantly decreased (P <0.05), and the changes of renal function and renal pathology were also lighter. Conclusion: Lipid peroxidation induced by oxygen free radicals is one of the important factors in the pathogenesis of renal damage in rats. Application of Salvia miltiorrhiza can significantly reduce the degree of renal pathological damage.