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目的 探讨妊娠高血压综合征(PIH)患者分娩后,不同时期是否存在内皮依赖性血管舒张功能受损.方法 146例PIH患者分娩后1、6周及24周行高频超声检测右侧肱动脉内皮依赖性血管舒张功能,对照组为125例正常妊娠分娩后女性.测量静息状态下右侧肱动脉内径(D1)、血流量(Q1)及反应性充血后内径(D2)、血流量(Q2);计算内径变化率(△D％)及血流量变化率(△Q％).结果 分娩后1、6周及24周PIH患者的△D％及△Q％均低于对照组(P＜0.001);PIH患者分娩后不同时期△D％及△Q％比较,差异无统计学意义(P＞0.05);分娩后不同时期PIH患者组内各亚组间△D％及△Q％两两比较,重度子痫前期患者均低于妊娠期高血压和轻度子痫前期患者(P＜0.05).结论 PIH患者分娩后存在内皮依赖性血管舒张功能受损,至少持续至分娩后24周时尚无明显恢复和改善,且重度子痫前期患者血管内皮功能受损程度更重.“,”Objective This study examines whether endothelium-dependent vasodilatation is impaired in patients with pregnancy-induced hypertension (PIH) at different times after delivery.Methods 146 cases of patients with PIH,1 week,6 weeks and 24 weeks,high frequency ultrasound right brachial artery endothelium-dependent vasodilation after delivery.The control group was 125 women with normal pregnancy after childbirth.The right brachial artery diameter (D1),blood flow (Q1) and reactive hyperemia internal diameter (D2),blood flow (Q2) were measured under resting condition.Calculate the change rate of internal diameter (△D％) and the change rate of blood flow (△Q％).Results The△D％ and△Q％ of patients with PIH at 1 week,6 weeks and 24 weeks after delivery were lower than those of the control group (P＜0.001).There was no significant difference (P＞0.05)in△D％ and△Q％ between PIH patients at different time after delivery.The △D％ and△Q％ of the subgroups of PIH patients in different periods after delivery were compared,Patients with severe preeclampsia were lower than those with gestational hypertension and mild preeclampsia (P＜0.05).Conclusions PIH patients with endothelium-dependent vasodilatation after childbirth,at least until 24 weeks after delivery was no significant recovery and improvement,and severe preeclampsia patients with vascular endothelial dysfunction more severe.