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对再生障碍性贫血病人的治疗,除骨髓移植外,免疫抑制疗法是最有效方法。应用抗淋巴细胞球蛋白(antilymphocyte globulin)或环孢菌素(cyclosporine)治疗已取得了最好的效果。据报道联合应用这两种药物治疗病人已取得成功,但没有进行对照试验以评价其疗效。病人和方法作者报告一项随机、多中心试验,对不适于骨髓移植的84例病人分为下列两组治疗。对照组41例,用抗淋巴细胞球蛋白和甲基强的松龙;环孢菌素组43例,除上述两药外加用环孢菌素。全部研究对象共用过两个批号的抗淋巴细胞球蛋白,其中38例的批号为1056-A0366,46例为 B0909。抗淋巴细胞球蛋白系通过中心静脉导管输入,在8～12小时内滴完,剂量为0.75ml/kg/d,连用8天;甲基强的
In addition to bone marrow transplantation, immunosuppressive therapy is the most effective treatment for patients with aplastic anemia. The best results have been achieved with antilymphocyte globulin or cyclosporine. It has been reported that the combination of these two drugs has been successful in treating patients, but no controlled trials have been conducted to evaluate their efficacy. Patients and Methods The authors report a randomized, multicenter trial of 84 patients not eligible for bone marrow transplantation in the following two groups. Control group, 41 cases, with anti-lymphocyte globulin and methylprednisolone; cyclosporin group 43 cases, in addition to the above two drugs plus cyclosporine. All subjects shared two batches of anti-lymphocyte globulin, 38 of which were 1056-A0366 and 46 were B0909. Anti-lymphocyte globulin through the central venous catheter input, drip completed within 8 to 12 hours, a dose of 0.75ml / kg / d, once every 8 days; methyl strong