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乳腺癌预后的判断是一众所关注的问题.目前虽有很多预测预后的方法:如肿瘤大小、组织学、核分级、激素受体、细胞增殖率、核倍体、生长因子受体、上皮生长因子受体基因及CathepsinD产物等等,但仍不能十分有效的判断预后.最近美国国立癌瘤中心发展联合会提出一项标准:肿瘤<1cm且无淋巴结转移的乳腺癌病人,术后10年复发率<10%,因此不必进行系统治疗,已被大家公认.然而>1cm乳腺癌病人预后判断仍需作进一步研究.本文综述近年来大家研究较多,并对乳腺癌预后判别较重要的的P~53基因、C—
The prognosis of breast cancer is a matter of concern. There are currently many methods for predicting prognosis: such as tumor size, histology, nuclear grade, hormone receptor, cell proliferation rate, nuclear ploidy, growth factor receptor, epithelium Growth factor receptor gene and CathepsinD production, but still can not be very effective in determining prognosis. Recently the National Cancer Center Development Association proposed a standard: breast cancer patients <1cm and no lymph node metastasis, 10 years after surgery The recurrence rate is less than 10%, so no systemic treatment is required, and it has been recognized by all. However, the prognosis of 1cm breast cancer patients still needs further study. This review has been widely studied in recent years, and is more important for the prognosis of breast cancer. P~53 gene, C-