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目的探讨术中冰冻病理对乳腺导管内乳头状肿瘤(IDPN)的诊断价值及相关影响因素。方法对2007年1月至2013年12月收治的560例术后石蜡病理确诊为乳腺IDPN的患者进行回顾性分析,对比术中冰冻病理与术后石蜡病理结果,观察术中冰冻病理诊断准确率及其相关影响因素。结果 1术中冰冻病理对于IDPN总体诊断准确率为85.1%,其中导管内乳头状瘤与导管内乳头状癌诊断准确率分别为88.9%、49.0%,差异有统计学意义(P<0.05);2 16例(3.1%)患者诊断病理级别升高,1例(0.2%)患者诊断病理级别降低;3伴有及不伴有乳头溢液患者诊断准确率分别为89.2%、79.4%,差异有统计学意义(P<0.05)。结论术中冰冻病理对于诊断IDPN意义重大,导管内乳头状瘤诊断准确率高于导管内乳头状癌,伴有乳头溢液患者比不伴有者术中冰冻病理诊断准确率高。
Objective To investigate the value of intraoperative frozen pathology in the diagnosis of intraductal papillary neoplasm (IDPN) and related influencing factors. Methods From January 2007 to December 2013, 560 patients with postoperative paraffin pathological diagnosis of breast IDPN were retrospectively analyzed. The intraoperative frozen pathology and postoperative paraffin pathology were compared. The accuracy of intraoperative frozen pathological diagnosis And its related factors. Results 1 The accuracy of IDPN in diagnosing intraoperative frozen pathology was 85.1%. The diagnostic accuracy of intraductal papilloma and intraductal papillary carcinoma were 88.9% and 49.0%, respectively, with statistical significance (P <0.05). Twenty-six patients (3.1%) had higher diagnostic pathological grade, and one patient (0.2%) had lower diagnostic pathological grade. The diagnostic accuracy rates of patients with and without papillary discharge were 89.2% and 79.4%, respectively Statistical significance (P <0.05). Conclusion The intraoperative frozen pathology is of great significance for the diagnosis of IDPN. The diagnostic accuracy of intraductal papilloma is higher than that of intraductal papillary carcinoma. The accuracy of intraoperative frozen pathological diagnosis is higher with nipple discharge than without.