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目的为探讨P_(53)、PCNA抗原在胃粘膜中的表达情况及其与胃癌发生的关系方法：应用LsAB免疫织化方法对80例胃粘膜进行了检测结果显了胃癌中P_(53)、PCNA强阳性表达率（80％、93．3％）明显高于异型增生（467％，53．3％）异型增生中P_(53)、PCNA强阳性表达率明显高于慢性萎缩性胃炎及慢性浅表性胃炎．结论研究结果表明，检测P_(53)、PCNA在肖粘膜中的不同表达，对胃癌发生机理的认识有重要意义．
Objective To investigate the expression of P_(53) and PCNA antigen in gastric mucosa and its relationship with the occurrence of gastric cancer. Methods: 80 cases of gastric mucosa were examined by immunohistochemical method of LsAB, and P_(53) was shown in gastric cancer. The strong positive expression rate of PCNA (80%, 93.3%) was significantly higher than that of dysplasia (467%, 53.3%). The strong positive expression rate of P_(53) and PCNA was significantly higher than chronic atrophic gastritis and chronic Superficial gastritis. Conclusion The results of the study show that the detection of P_(53) and PCNA in different expressions of the epileptic mucosa are important for understanding the mechanism of gastric cancer.