氨噻肟头孢菌素(Cefotaxime)在试管内对肠杆菌有良好的抗菌活性,对革兰氏阳性球菌活性也很高。但关于其临床应用的资料却很少。本文报道该药治疗严重感染的应用经验。35例患者应用氨噻肟头孢菌素38个疗程。患者年龄17～88岁,平均55.2岁,男19例,女16例。32例患者有如下疾病:器质性心脏病、慢性阻塞性肺病、肾功能衰竭、恶性肿瘤、粒细胞减少症、手术后并发症、糖尿 Cefotaxime has good antibacterial activity against Enterobacteriaceae in vitro and high activity against Gram-positive cocci. However, there is very little information on its clinical application. This article reports the drug’s experience in treating severe infections. Thirty-five cycles of cefotaxime were administered to 35 patients. Patients aged 17 to 88 years, mean 55.2 years, 19 males and 16 females. 32 patients had the following diseases: structural heart disease, chronic obstructive pulmonary disease, renal failure, malignancy, neutropenia, postoperative complications, diabetes