有关寄生蠕虫感染者抗体各组分反应的基因调节所知甚少,了解这类基因调节对解释血清学诊断结果是至关重要的。免疫沉淀和SDS-PAGE的联合使用是分析对具复杂抗原性感染物起反应的抗体组分的有力工具。作者以此检测了放射性碘标记的蛔虫幼虫分泌物。感染兔血清能识别碘标记的幼虫分泌物的所有组分,但感染大鼠或小鼠血清则只与这些分泌物组分中的某些 Little is known about the regulation of the gene response of individual components of parasitic helminth infections, and understanding the regulation of such genes is crucial to interpreting the serological diagnosis. The combined use of immunoprecipitation and SDS-PAGE is a powerful tool for the analysis of antibody components that react to complex antigenic infectious agents. The authors examined radioactive iodine-labeled worms larvae secretions. Infected rabbit sera can recognize all components of iodine-labeled larval secretions, but infected rat or mouse sera are only associated with some of these secretions components