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在乙醇和水的混合溶液中,将N,N′-二(邻氧乙酸)苄叉丙二胺(1)与氯化铜反应,获得配合物Cu(Ⅱ)L1.H2O.0.25CH3CH2OH(2)[L1=N,N′-二(邻氧乙酸)苄叉丙二胺];当将反应混合溶液的pH值调至8~9,获得Cu(Ⅱ)ClL2.3H2O(3)[L2=N-(邻氧乙酸)苄叉丙二胺];将N,N′-二(邻氧乙酸)苄叉丙二胺(1)与氯化镍反应,获得配合物Ni(Ⅱ)L1.2.75H2O(4).用元素分析、1H NMR和IR谱等方法对所合成的化合物1和配合物2~4进行了表征,并测定了配合物2~4的晶体结构.在配合物2中,铜原子为六配位[CuN2O4],在配合物3中,铜原子为六配位[CuN2O3Cl],在配合物4中,镍原子为六配位[NiN2O4],三个配合物均为畸变八面体结构.抑菌活性大小的顺序:配合物3>配合物2>化合物1.
The complex of Cu (Ⅱ) L1.H2O.0.25CH3CH2OH (2) was obtained by the reaction of N, N’-bis (o-oxyacetic acid) benzylidenepropylenediamine (1) with cupric chloride in a mixed solution of ethanol and water ) [L1 = N, N’-bis (o-oxyacetic acid) benzylidenepropylenediamine]; when the pH of the reaction mixture is adjusted to 8-9, Cu (II) ClL2.3H2O (3) [L2 = N, N’-bis (o-oxyacetic acid) benzylidenepropylenediamine (1) with nickel chloride to obtain the complex Ni (Ⅱ) L1.2.75 H2O (4) .The synthesized compounds 1 and complexes 2 ~ 4 were characterized by elemental analysis, 1H NMR and IR spectra, and the crystal structures of complexes 2 ~ 4 were determined.In the complex 2, The copper atom is hexacoordinated [CuN2O4]. In the complex 3, the copper atom is hexacoordinated [CuN2O3Cl]. In the complex 4, the nickel atom is hexacoordinated [NiN2O4] and the three complexes are all distorted Surface structure and order of antibacterial activity: Complex 3> Complex 2> Compound 1.