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为了探讨雌、孕激素受体与外阴营养不良、恶性肿瘤的关系，用葡聚糖-活性碳单点饱和分析法测定了31例外阴营养不良（增生型14例、混合型10例、萎缩型7例）和19例外阴恶性肿瘤（外阴鳞形细胞癌16例）的雌、孕激素受体（ER、PR）含量。结果：ER的含量混合型高于萎缩型，PR的含量混合型高于增生型，增生型高于萎缩型（P值均＜0．05）；外阴营养不良及其邻近正常组织的ER与PR的含量之间呈正相关关系（P＜0．01），外阴鳞状细胞癌PR的含量随分化程度的降低而逐渐降低，且癌组织PR含量明显低于其邻近的正常组织。以上结果为外阴营养不良的内分泌治疗提供了理论依据，在外阴恶性肿瘤中，PR可作为判断预后的指标之一。
In order to investigate the relationship between estrogen and progesterone receptors and vulvar dystrophy and malignancy, 31 cases of dystrophy were determined by dextran-activated carbon single point saturation assay (14 cases of proliferative, 10 cases of mixed, and atrophic 7 cases and 19 cases of malignant tumors (16 cases of vulvar squamous cell carcinoma) of estrogen and progesterone receptor (ER, PR) content. Results: The content of ER was higher than that of atrophic type, the content of PR was higher than that of proliferative type, the proliferative type was higher than that of atrophic type (P<0.05); genital dystrophy and ER and PR of adjacent normal tissues. There was a positive correlation between the content of PR (P<0.01), and the content of PR in vulvar squamous cell carcinoma decreased gradually with the decrease of differentiation, and the PR content of cancer tissue was significantly lower than that of adjacent normal tissue. The above results provide a theoretical basis for the endocrine therapy of vulvar dystrophy. In the vulvar malignant tumors, PR can be used as one of the indicators of prognosis.