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近年来由于采用联合化疗,白血病的疗效有所提高,患者生存期限逐渐延长,但绝大多数抗白血病药物不能通过血脑屏障,急性白血病的神经系统受累率逐年增高,确实值得注意。中枢神经系统白血病可发生在白血病的各种类型及各个病程时期,其中枢神经系统损害常见临床表现有脑出血、颅内压增高,进行性多病灶性白质脑病、脊髓损害、脑干颅神经核或颅神经损害、神经根和周围神经损害等。白血病死于脑出血者多见,首现症状以神经系统损害者则较少,且常被忽略,为增进对中枢神经白血病的认识,现将我院内科近期收治的4例报告如下,以供临床参考。
In recent years, due to the use of combination chemotherapy, the efficacy of leukemia has increased, patients’ life span gradually extended, but the vast majority of anti-leukemia drugs can not cross the blood-brain barrier, acute leukemia neurological involvement rate increased year by year, is indeed worth noting. Central nervous system leukemia can occur in various types of leukemia and various stages of disease, the central nervous system damage common clinical manifestations of cerebral hemorrhage, increased intracranial pressure, progressive multifocal encephalopathy, spinal cord injury, brain stem cranial nerve nucleus Or cranial nerve damage, nerve root and peripheral nerve damage. Leukemia is more common in patients with cerebral hemorrhage, the first symptom of neurological damage is less, and often overlooked, in order to promote awareness of CNL, now in our hospital 4 cases recently admitted for the following, for Clinical reference.