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组合化学的发展促进了新药和新材料的开发与研制,这种方法的有效性取决于如何快速组建化合物库。为满足这个要求,利用极快速反应闪速合成目标化合物成为研究的焦点。速度的加快必然对反应过程的高度控制提出新的挑战。微反应器因具有高效的传热与传质以及对滞留时间可控的优势而成为控制极快反应的良好技术。闪速化学(flash chemistry)便是采用能被控制的快速反应来合成目标化合物的新方法。本文系统介绍了闪速化学的基本概念、特点及其应用,重点综述了近五年来闪速化学在有机合成以及聚合物合成中的研究进展,并对其发展前景进行了展望。
The development of combinatorial chemistry has led to the development and development of new drugs and new materials. The effectiveness of this method depends on how to rapidly set up a compound library. To meet this requirement, the use of very fast reaction flash synthesis of the target compound has become the focus of research. The speed of the inevitable response to the high degree of control of the process put forward new challenges. Microreactors are a good technique for controlling very fast reactions due to their efficient heat and mass transfer and their controllable residence time. Flash chemistry is a new method of synthesizing a target compound with a rapid reaction that can be controlled. This paper systematically introduces the basic concepts, characteristics and applications of flash chemistry. The progress of flash chemistry in organic synthesis and polymer synthesis in recent five years is reviewed. The development prospect of flash chemistry is also forecasted.