To review the cardiac protective effects of wine intake and recommend moderate wine consumption as a primary prevention strategy for coronary artery diseases (CAD). Systematically review former studies on the wine con-sumption (red wine and yellow wine) by searching the Medline database and other related citations, and investigate possible protective pathways. Regular moderate wine intake can benefit heart from acute coronary symptom (ACS) at-tacking; reduce the relative risk of morbidity and mortality from CAD. It might not be imperative to ask people to stop drinking; inversely, we suggest moderate wine consumption as a preventive strategy in CAD for its guarding contribu-tion.