论文部分内容阅读
本文应用去甲肾上腺素(Noradrenaline NA)在大鼠提睾肌上制作微循环障碍动物模型,从微血管管径变化角度观察了川芎嗪的作用.结果表明:川芎嗪组(川芎嗪+NA)静注川芎嗪,对NA表面灌流引起的微血管收缩有抑制作用,可扩张微血管的管径。第1级分枝动脉(A_1)和第2级分枝静脉(V_1),在NA灌流浓度1.0×10~(-5)～1.0×10~(-3)mol/L投与时与第1对照组(NA)、第2对照组(NA+生理盐水)比较均有非常显著性差异(P<0.01),可见川芎嗪对微循环障碍有较肯定的改善作用。
In this study, noradrenaline NA was used to make animal models of microcirculatory disturbance in cremaster muscle of rats. The effect of tetramethylpyrazine was observed from the perspective of microvascular diameter change. The results showed that the tetramethylpyrazine group (tetramethylpyrazine + NA) was static. Note: Ligustrazine has inhibitory effects on the microvasculature contraction induced by perfusion of NA surface, and can expand the diameter of the microvessels. Grade 1 branch arteries (A_1) and grade 2 branch veins (V_1) were compared with control group 1 at NA perfusion concentrations of 1.0×10 -5 - 1.0×10 -3 mol/L. The group (NA) and the second control group (NA + physiological saline) all had very significant differences (P <0.01), showing that the tetramethylpyrazine has a more positive effect on microcirculation.